ParkinsonCanadaV1, Main, Exploration, bibRecord, 003B64

Potential signalling roles for utp and udp: sources, regulation and release of uracil nucleotides

Identifieur interne : 003B64 ( Main/Exploration ); précédent : 003B63; suivant : 003B65

Potential signalling roles for utp and udp: sources, regulation and release of uracil nucleotides

Auteurs : C. M. Anderson [Canada] ; F. E. Parkinson [Canada]

Source :

Trends in Pharmacological Sciences [ 0165-6147 ] ; 1997.

RBID : ISTEX:905AF39634A1790819C5C31E08A1BA885AEBED25

English descriptors

KwdEn :
- Animals, Humans, Signal Transduction (physiology), UDP, UTP, Uracil Nucleotides (physiology), Uridine Diphosphate (physiology), Uridine Triphosphate (physiology), cellular uptake mechanisms, pyrimidinoceptors, synthesis, uracil nucleotides, uridine.
MESH :
- chemical , physiology : Uracil Nucleotides, Uridine Diphosphate, Uridine Triphosphate.
- physiology : Signal Transduction.
- Animals, Humans.

Abstract

Increasing evidence for receptors for uracil nucleotides has focused interest on specific signalling mechanisms involving UTP and UDP. At least three metabotropic P2 receptors are stimulated by uracil nucleotides with equal or greater potency than by adenine nucleotides, and there might be ionotropic receptors as well. Regulation of uridine and uracil nucleotide levels is important when considering the receptor-mediated effects of these compounds. Cells can synthesize uracil nucleotides de novo or by salvage of uridine. UTP made from salvage might be preferentially used for RNA synthesis in the nucleus, while UTP synthesized de novo seems to be used for UDP-sugar and CDP-phospholipid production. UTP from both pathways can enter a free UTP pool, from which UTP can be released from cells. UTP and UDP can stimulate pyrimidinoceptors, but metabolism by ecto-nucleotidases limits their effects. Alternatively, UTP might be a substrate for ecto-protein kinases, and this could contribute to its extracellular regulation. Cells can reclaim uridine, using nucleoside transport processes, following dephosphorylation of UTP, UDP and UMP. In this article Christopher Anderson and Fiona Parkinson discuss how understanding the processes that regulate uridine and uracil nucleotide concentrations will enhance our ability to manipulate UTP/UDP signalling pathways for pharmacological effect.

Url:

DOI: 10.1016/S0165-6147(97)01106-1

Affiliations:

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La maladie de Parkinson au Canada (serveur d'exploration)

Potential signalling roles for utp and udp: sources, regulation and release of uracil nucleotides

Potential signalling roles for utp and udp: sources, regulation and release of uracil nucleotides

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
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